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. 2019 Jul 30;10:968. doi: 10.3389/fphys.2019.00968

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Copyright © 2019 Zhu, Li, Wang, Zheng, Hoque, Lv and Zeng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mechanisms of GSK3α/β regulate sperm motility and acrosome reaction. Sperm GSK3α/β is accumulated during the maturation in the epididymis. The phosphorylation of GSK3α/β led to GSK3α/β inactive, which resulted in enhancing sperm energy metabolism involved in oxidative phosphorylation and glycolysis, thus regulating sperm function. MDH, malate dehydrogenase; SDH, succinate dehydrogenase; LDH, lactate dehydrogenase; ATP, adenosine triphosphate.