Figure 3.

(A) Scatter plot between the actual and predicted energy-manic symptom scores for the model based on the pattern of activation within the bilateral ventrolateral prefrontal cortex during uncertain reward expectancy in the second sample. The correlation coefficient (r) and the mean squared error between the actual and predicted energy-manic symptom scores were .33 (p = .009) and 9.37 (p = .04), respectively. (B) Scatter plot between the actual and predicted energy-manic symptom scores for the model based on patterns of whole-brain activation during uncertain reward expectancy in the second sample. The correlation coefficient (r) and the MSE between the actual and predicted energy manic scores were .33 (p = .01) and 8.61 (p = .01), respectively. For visualization purposes, subjects were color coded according to the categorically defined diagnoses to emphasize the transdiagnostic nature of the findings. Some subjects, however, presented with symptoms that did not meet the threshold for a DSM-5 diagnosis.