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. 2019 Jul 30;13:339. doi: 10.3389/fncel.2019.00339

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Copyright © 2019 Zhang, Zhao, Zhang, Yu, Wang and Chang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The characterization of PrP^C binding to Aβ42. (A) The regions involved in PrP^C binding to amyloid-β (Aβ). The green lines represent the amino acid sequence of PrP^C involved in binding to Aβ. The residue 95–110 region of PrP^C contains the critical amino acid sequence for binding oligomeric Aβ. (B) A diagram depicting the binding of amyloid-β (Aβ) in various aggregation states to PrP^C. The green represents the molecular weights of Aβ assemblies bound to PrP^C published in previous studies. The Y-axis represents the molecular weight of the various Aβ42 oligomers. ADDL, Aβ-derived diffusible ligand.