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. 2019 Jul 30;13:702. doi: 10.3389/fnins.2019.00702

FIGURE 1.

FIGURE 1

Anxiety-like behavior and locomotion and in 3, 5, and 7-month-old WT and A53T mice. (A) The timeline of the experimental procedure. Both WT and A53T animals (3, 5, and 7 months) were subjected to a behavioral test battery consisting of elevated plus maze (EPM) and open field test (OFT). Tests were conducted 7 days apart. Three days following OFT, animals were perfused and brains were collected. (B) The A53T mice spent more time in open arms of EPM compared to WT animals at 5 and 7 months of age. A progressive reduction of anxiety-like behavior was observed in the A53T mice. (C) The A53T animals covered more distance in the EPM at both 5 and 7 months of age. (D) Compared to age-matched controls, 5- and 7-month A53T mice spent more time in the center of the open field. (E) The A53T mice covered significantly more distance than WT animals at both 5 and 7 months of age. An aging-induced increase in locomotion was also observed in A53T mice (n = 10/group; *p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.005).