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. 2019 Jul 30;13:702. doi: 10.3389/fnins.2019.00702

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Copyright © 2019 Stanojlovic, Pallais and Kotz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CNO effects on anxiety-like behavior and locomotion in 5-month orx-Cre male mice. Young 5-month mice received intracranial injections of control DREADD virus (cDREADD, pAAV-hSyn-DIO-mCherry). (A,B) CNO treatment did not affect distance traveled or time spent in open arms in EPM. (C,D) The time spent in open arms was not affected by CNO treatment as well as time spent in center of the OFT arena (n = 7/group).