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. 2019 Jul 30;10:856. doi: 10.3389/fphar.2019.00856

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Copyright © 2019 Rong, Wan, Fan, Liu, Sun, Huo, Zhang, Li, Xie, Wang and Sun

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of amentoflavone on the expression of inflammatory cytokines in the hippocampus by PTZ-induced kindling. (A) Representative immunoblots of IL-1β, IL-18, and TNF-α proteins in different groups. (B–D) Semi-quantitative analysis of the relative levels of IL-1β, IL-18, and TNF-α by densitometric analysis (n = 6 mice per group, Student’s t test). (E–G) Semi-quantitative analysis of the relative levels of IL-1β, IL-18, and TNF-α using ELISA (n = 9 mice per group, Student’s t test). Error bars represent mean ± s.d. *, **, *** represent p < 0.05, p < 0.01, p < 0.001, respectively. PTZ, pentylenetetrazole; AF, amentoflavone.