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. 2019 Jul 1;9(7):1354–1366.

Figure 2.

Figure 2

Targeting lncRNA to treat cancer. ① ASOs-mediated knock down of cytoplasmic and nuclear lncRNA transcription levels through RNaseH-dependent degradation. ② CRISPR-cas9 based knock-out strategy of lncRNA via specific gDNA. ③ Two methods of virus therapy, encapsulated shRNA or lncRNA-mediated knock down or up-regulation of targeted lncRNA, or NATs-mediated down-regulation of lncRNA elevating the expression of neighboring tumor suppressor genes. ④ Nano-carrier-absorbed on nanodrugs detached within cytoplasm after specific stimulation.