Table 2.
Plasma concentrations of main primary and secondary bile acid species in healthy controls and p.Ser267Phe variants
Concentration values are mean ± S.D.
| Healthy controls (n = 43) | p.Ser267Phe (n = 15) | p value, healthy controls/p.Ser267Phe | |
|---|---|---|---|
| nm | nm | ||
| CA | 86.9 ± 135.2 | 819.2 ± 1088.1 | 0.000 |
| TCA | 263.8 ± 614.5 | 17,434.1 ± 15,473.8 | 0.000 |
| GCA | 1176.7 ± 3165.5 | 57,694.9 ± 48,102.9 | 0.000 |
| CDCA | 301.2 ± 414.8 | 615.2 ± 426.1 | 0.000 |
| TCDCA | 687.3 ± 1023.8 | 7606.3 ± 8174.4 | 0.000 |
| GCDCA | 3581.3 ± 3957.4 | 67,109.77 ± 44,185.9 | 0.000 |
| DCA | 274.3 ± 491.7 | 210.4 ± 238.8 | 0.576 |
| TDCA | 43.2 ± 72.1 | 81.2 ± 193.2 | 0.776 |
| GDCA | 248.1 ± 435.8 | 1556.5 ± 4825.7 | 0.852 |
| LCA | 3.98 ± 4.07 | 3.64 ± 6.47 | 0.093 |
| TLCA | 1.21 ± 1.99 | 0.43 ± 0.58 | 0.192 |
| GLCA | 14.42 ± 27.68 | 31.94 ± 98.7 | 0.299 |