Table 3.
Plasma concentrations of some sulfated bile acids species in healthy controls and p.Ser267Phe variants
Concentration values are mean ± S.D.
| Healthy controls (n = 43) | p.Ser267Phe (n = 15) | p value, healthy controls/p.Ser267Phe | |
|---|---|---|---|
| nm | nm | ||
| CA-3–sulfated | 1.4 ± 1.89 | 3.3 ± 2.2 | 0.000 |
| GCA-3–sulfated | 1.82 ± 2.49 | 9.77 ± 10.31 | 0.000 |
| DCA-3–sulfated | 1.49 ± 2.54 | 0.95 ± 2.62 | 0.023 |
| GDCA-3–sulfated | 77.99 ± 117.99 | 166.04 ± 574.13 | 0.086 |
| TDCA-3–sulfated | 12.86 ± 28.58 | 0.1 ± 0.11 | 0.233 |
| TCDCA-3–sulfated | 98.19 ± 205.54 | 0.8 ± 1.08 | 0.136 |
| TLCA-3–sulfated | 0.68 ± 1.28 | 0.06 ± 0.07 | 0.025 |
| GLCA-3–sulfated | 130.94 ± 261.36 | 400.84 ± 1479.65 | 0.011 |
| GUDCA-3–sulfated | 131.02 ± 132.24 | 1679.92 ± 3229.69 | 0.001 |
| TUDCA-3–sulfated | 16.2 ± 27.76 | 0.64 ± 0.74 | 0.435 |