Figure 2.

Conditional deletion of Phlpp1 using Ctsk–Cre increases distal femur bone volume and bone mineral density. Female Phlpp1 cKO_Ctsk mice (n = 3) and Cre⁺ control littermates (n = 3) were aged to 12 weeks. A, representative radiographs of Cre⁺ control and Phlpp1 cKO_Ctsk hind limbs were generated. Micro-CT analyses were performed at the distal femur. Shown are (B) reconstructions from Cre⁺ control and (C) Phlpp1 cKO_Ctsk distal femurs, (D) bone volume per total volume, (E) bone mineral density, (F) bone volume, (G) trabecular number, (H) trabecular spacing, and (I) trabecular thickness. ***, p < 0.005; **, p < 0.01; *, p < 0.05.