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Osteoclast-specific deletion of Phlpp1 increases vertebral body bone volume. Female Phlpp1 cKOCtsk mice (n = 3) and Cre+ control littermates (n = 3) were aged to 12 weeks and μCT analyses of the L5 cranial region of the vertebrae were performed. Shown are: (A) connective density, (B) trabecular number, (C) trabecular spacing, (D) trabecular thickness, (E) bone volume and (F) SMI. ***, p < 0.005; *, p < 0.05. SMI, structure model index.
