Figure 4.
Anti-adaptor regulation of RpoS degradation. A, three differently characterized anti-adaptors are shown in green, with their known upstream transcriptional regulators. The regulator mediating the response to DNA damage is not known. B, pathway for adaptor-mediated degradation of RpoS and anti-adaptor regulation of this process is shown. RpoS (σS) is shown in yellow. Adaptor RssB is shown in blue, both in phosphorylated and unphosphorylated form. The ClpXP protease is shown in gray; the details of binding of RpoS and RssB to ClpXP are not fully understood.