Table 1.

Treatment of extravasation

Drug	Intervention	Advice
DOX	DMSO	Apply locally immediately of a known/suspected DOX EV
	Dexrazoxane	Administer within 3–6 h of a known/suspected DOX EV
	Ice packs	Apply immediately of a known/suspected DOX EV
Vinca Alkaloids	Hyaluronidase	Instil 1 mL hyaluronidase (150 U mL−1) for every 1 mL of extravasated drug through the existing catheter line
	Hot packs	Apply immediately of a known/suspected vinca alkaloids EV