Table 3.
Relationship of urinary corrected melamine levels with doubling of serum creatinine levels and ESKD
| Urinary Corrected Melamine Levels | Event N (%)/Total Person-Yr | Crude HR (95% CI) | Adjusted HR (95% Cl)a |
|---|---|---|---|
| Doubling of serum creatinine levels | |||
| Tertile 1b | 18 (18)/686 | Reference | Reference |
| Tertile 2 | 25 (26)/590 | 1.70 (0.92 to 3.12) | 1.88 (0.99 to 3.55) |
| Tertile 3 | 37 (38)/568 | 2.62 (1.49 to 4.60) | 2.30 (1.25 to 4.23) |
| ESKD | |||
| Tertile 1b | 7 (7)/705 | Reference | Reference |
| Tertile 2 | 15 (16)/637 | 2.59 (1.05 to 6.37) | 2.77 (1.06 to 7.19) |
| Tertile 3 | 12 (12)/638 | 2.01 (0.79 to 5.10) | 1.45 (0.52 to 4.07) |
HR, hazard ratio; 95% CI, 95% confidence interval.
a
Adjusting for age, sex, body mass index, angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker usage, diabetes mellitus, hypertension, eGFR, and urinary protein-to-creatinine ratio cut at 1 g/g.
b
Three tertiles of urinary corrected melamine levels (micrograms per millimole) were 0.02–0.58, 0.59–1.46, and 1.47–12.7, with cutoffs of at 0.58 and 1.46 μg/mmol.