Table 1.
Baseline characteristics and kidney biopsy results of older adults diagnosed with IgA nephropathy in 23 centers belonging to the Spanish Group for the Study of Glomerular Diseases
| All Patients, n=151 | Asymptomatic Urinary Abnormalities, n=84 | Hematuria-Related AKI, n=53 | Crescentic AKI, n=8 | Nephrotic Syndrome, n=6 | |
|---|---|---|---|---|---|
| Men (%) | 116 (77) | 68 (81) | 37 (70) | 7 (87) | 4 (67) |
| Age, yr | 72±5 | 71±4a,b,c | 74±5 | 74±4 | 75±7 |
| Diabetes mellitus, n (%) | 39 (26) | 24 (29) | 13 (25) | 2 (25) | 0 |
| Systolic BP, mm Hg | 142±20 | 141±15d | 140±22 | 155±27 | 149±37 |
| Diastolic BP, mm Hg | 78±11 | 79±11 | 77±12 | 82±9 | 76±9 |
| Serum creatinine, mg/dl | 3±2.3 | 2.1±1.4b,c | 4.3±2.8 | 4.7±2.1 | 1.4±0.6e |
| eGFR, ml/min per 1.73 m2 | 32±22 | 39±22b,c | 19±16 | 15±10 | 54±26e |
| Proteinuria, g/d | 2.1 (1–4.1) | 2.1 (0.8–3.8) | 1.2 (0.8–3.5) | 7 (2.1–7.6) | 4.5 (3.5–6.3)f |
| Macroscopic hematuria, n (%) | 45 (30) | 0 (0)b | 41 (77) | 4 (50) | 0 (0)e,g |
| Duration of macroscopic hematuria, d | 11±33 | 0 | 27±47 | 2±3.2 | 0 |
| Microscopic hematuria, n (%) | 130 (85) | 65 (80)c | 53 (100) | 8 (100) | 6 (100)e |
| Oral anticoagulant therapy (%) | 30 (20) | 11 (13)c | 18 (34) | 0 | 1 (17) |
| KRT at presentation, n (%) | 14 (9) | 1 (1)b,c | 10 (20) | 3 (37) | 0 (0)e,g |
| M1 (%) | 100 (66) | 49 (58)h | 39 (74) | 6 (75) | 6 (100) |
| E1 (%) | 42 (28) | 17 (20) | 18 (34) | 3 (37) | 4 (40) |
| S1 (%) | 56 (37) | 35 (42) | 17 (32) | 2 (25) | 2 (25) |
| T1–T2 (%) | 77 (51) | 41 (49) | 28 (53) | 5 (62) | 3 (50) |
| ATN (%) | 59 (39) | 19 (23)i | 35 (66) | 3 (38) | 2 (33) |
| Glomeruli with crescents (%) | 0.21±0.4 | 2±6d | 3±7j | 53±5.8 | 7±10k |
KRT, kidney replacement therapy; M1, mesangial hypercellularity; E1, endocapillary hypercellularity; S1, segmental glomerulosclerosis; T1–T2, tubular atrophy/interstitial fibrosis >25%; ATN, acute tubular necrosis.
P=0.00 versus nephrotic syndrome.
P<0.001 versus crescentic AKI.
P<0.001 versus hematuria-related AKI.
P=0.02 versus crescentic AKI.
P<0.001 versus hematuria-related AKI.
P=0.02 versus hematuria-related AKI.
P=0.04 versus crescentic AKI.
P=0.04 versus nephrotic syndrome.
P=0.03 versus hematuria-related AKI.
P=0.00 versus crescentic AKI.
P<0.001 versus crescentic AKI.