Table 2.
Clinical studies published at www.clinicaltrials.gov in which a compound with holmium-166 is used
| Study title | Device/ drug | Tumour type | Compound | Sponsor | Time path | ClinicalTrials.gov Identifier | Reference(s) |
|---|---|---|---|---|---|---|---|
| QuiremSpheres Observational Study | device | Liver cancer, non-resectable tumors | Holmium-166 polylactic microspheres | Terumo Europe N.V. | 2018 - (recruiting) | NCT03563274 | |
| Holmium Radioembolization as Adjuvant Treatment to RFA for Early Stage HCC: Dose Finding Study | device | hepatocellular carcinoma | RFA + Holmium-166 polylactic microspheres | Leiden University Medical Center The Netherlands | 2018 - (recruiting) | NCT03437382 | |
| HEPAR Primary: Holmium-166-radioembolization in Hepatocellular Carcinoma Patients | device | hepatocellular carcinoma |
SIRT Holmium-166 PLLA microspheres |
Erasmus Medical Center Rotterdam, University Medical Center Utrecht The Netherlands | 2017 - (recruiting) | NCT03379844 | |
| Feasibility of Holmium-166 Micro Brachytherapy in Head and Neck Tumors | device | head-and-neck neoplasms |
SIRT Holmium-166 PLLA microspheres |
University Medical Center Utrecht The Netherlands |
2016–2018 (terminated, slow accrual) |
NCT02975739 | |
| Holmium-166-radioembolization in NET After Lutetium-177-dotatate; an Efficacy Study | device | neuroendocrine tumours in the liver |
SIRT Holmium-166 PLLA microspheres |
University Medical Center Utrecht, The Netherlands | 2016 - (recruiting) | NCT02067988 | (Braat et al. 2018b; van Nierop et al. 2018) |
| Surefire Infusion System vs. Standard Microcatheter Use During Holmium-166 Radioembolization | device | colorectal metastases in the liver |
SIRT Holmium-166-PLLA microspheres |
University Medical Center Utrecht The Netherlands | 2016 - (recruiting) | NCT02208804 | (van Nierop et al. 2018; van den Hoven et al. 2016) |
| Radioactive Holmium Microspheres for the Treatment of Unresectable Liver Metastases | device | liver neoplasms |
SIRT Holmium-166-PLLA microspheres |
University Medical Center Utrecht The Netherlands |
2012–2015 (completed) |
NCT01612325 | (Prince et al. 2018; Braat et al. 2018a; Prince et al. 2015; van Nierop et al. 2018) |
| Radioactive Holmium Microspheres for the Treatment of Liver Metastases | device |
liver metastases liver tumours |
SIRT Holmium-166-PLLA microspheres |
University Medical Center Utrecht Utrecht, Netherlands |
2009–2012 (completed) |
NCT01031784 | (Smits et al. 2012; van de Maat et al. 2013; Smits et al. 2013; Smits et al. 2010; Prince et al. 2014; Elschot et al. 2014; Braat et al. 2018a; van Nierop et al. 2018) |
| Radiation Therapy Using Holmium Ho 166 DOTMP Plus Melphalan and Peripheral Stem Cell Transplantation in Treating Patients With Multiple Myeloma | drug | multiple myeloma and plasma cell neoplasm |
melphalan + Holmium-166- DOTMP |
Fred Hutchinson Cancer Research CenterSeattle, Washington, United States |
2004–2010 (completed) |
NCT00004158 | |
| Melphalan With or Without Holmium Ho 166 DOTMP Followed by Peripheral Stem Cell Transplantation in Treating Patients With Multiple Myeloma | drug | multiple myeloma and plasma cell neoplasm |
melphalan + Holmium-166- DOTMP |
Fred Hutchinson Cancer Research Center Seattle, Washington, United States |
2004–2010 (completed) |
NCT00008229 | |
| Study Comparing STR (Skeletal Targeted Radiotherapy) Plus Melphalan to Melphalan Alone, With Stem Cell Transplant in Multiple Myeloma | drug | multiple myeloma | Holmium-166- DOTMP | Poniard Pharmaceuticals |
2004–2009 (terminated) |
NCT00083564 | (Giralt et al. 2003; Breitz et al. 2003b) |
| Holmium Ho 166 DOTMP Followed by Peripheral Stem Cell Transplantation in Treating Patients With Metastatic Ewing's Sarcoma or Rhabdomyosarcoma That Has Spread to the Bone | drug | metastatic cancer, sarcoma | Holmium-166- DOTMP | Fred Hutchinson Cancer Research Center Seattle, Washington, United State |
2003–2011 (completed) |
NCT00006234 | |
| Chemotherapy, Holmium Ho 166 DOTMP, and Peripheral Stem Cell Transplantation in Treating Patients With Multiple Myeloma | drug | multiple myeloma and plasma cell neoplasm | Holmium-166- DOTMP | Poniard Pharmaceuticals |
2003–2009 (completed) |
NCT00045136 | |
| A Trial of Skeletal Targeted Radiotherapy Using Holmium-166-DOTMP in Patients With Multiple Myeloma | drug | multiple myeloma | Holmium-166-DOTMP | Poniard Pharmaceuticals |
2002–2009 (terminated, business reasons) |
NCT00039754 |