Fig. 1.
Cross-study comparison of PK for a pertuzumab [7, 9, 11] and b trastuzumab [7, 11, 14]. Cmax,ss steady-state peak (maximum) serum concentration, Cmin,ss steady-state serum trough (minimum) concentration, PK pharmacokinetic. Cycle numbers for Cmin,ss and Cmax,ss vary between studies. Cmin,ss: JACOB, Cycle 3 pre-dose; JOSHUA, Cycle 4 pre-dose; CLEOPATRA, Cycle 9 pre-dose; ToGA, Cycle 9 pre-dose. Cmax,ss: JACOB, Cycle 4 post-dose; JOSHUA, Cycle 4 post-dose; CLEOPATRA, Cycle 9 post-dose; ToGA, Cycle 5 post-dose. Red bars = Cmin; blue bars = Cmax; lower and upper ends of each box plot = 25th and 75th percentile exposure value; horizontal white line = median per group; points = individual PK data. Brackets extending from the ends of the box are drawn to the nearest value, not beyond 1.5 times the interquartile range