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. 2019 Jul 12;11(7):1581. doi: 10.3390/nu11071581

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) Scheme of the effects and pathway activation of H₂S-donors in cell: Akt activation, Erk1/2 activation, Ang-1 upregulation, NF-kB sulfidration, Nrf2 activation by sulfidration of Keep1 and upregulation of CBS, CSE and antioxidant enzyme (NQO1, HO1, etc.), opening K_ATP channels; (B) effects of H₂S on insulin release under hyperglycemic conditions ( inhibition) at late stage of diabetes in beta cells: upregulation of CSE and CBS ; MST ; closure of L-type voltage-dependent Ca²C channels , opening of K_ATP channels , and hyperpolarization.

Inline graphic — (A) Scheme of the effects and pathway activation of H₂S-donors in cell: Akt activation, Erk1/2 activation, Ang-1 upregulation, NF-kB sulfidration, Nrf2 activation by sulfidration of Keep1 and upregulation of CBS, CSE and antioxidant enzyme (NQO1, HO1, etc.), opening K_ATP channels; (B) effects of H₂S on insulin release under hyperglycemic conditions ( inhibition) at late stage of diabetes in beta cells: upregulation of CSE and CBS ; MST ; closure of L-type voltage-dependent Ca²C channels , opening of K_ATP channels , and hyperpolarization.