Table 1.

Body and brain weights, and survival rates of young and old mice treated with sesame lignans or vehicle.

	YC	YS0.05	OC	OS0.02	OS0.05
Body weight (g)	30.1 ± 0.3 ab	28.8 ± 0.4 a	30.9 ± 0.9 ab	33.2 ± 1.5 bc	35.0 ± 1.1 c
Brain weight (mg)	467.7 ± 0.3 a	467.2 ± 0.4 a	469.5 ± 0.4 a	465.6 ± 0.5 a	468.8 ± 0.3 a
Final survival rate (%)	90	85	64	75	64

Values are the mean ± SEM. Statistical analyses were performed using a one-way ANOVA followed by a Tukey–Kramer post hoc analysis. Different letters indicate significant differences (p < 0.05). Experimental groups are indicated as: Young control, fed basal diet (YC, n = 18), young, fed basal diet supplemented with 0.05% sesame lignans (YS0.05, n = 17), old control, fed basal diet (OC, n = 18), old, fed basal diet supplemented with 0.02% sesame lignans (OS0.02, n = 12), and old, fed diet supplemented with 0.05% sesame lignans (OS0.05, n = 18). One mouse in the YC group, one mouse in the OC group, and three mice in the OS0.05 group died one month after the step-through test.