Effects of whole linseed, defatted linseed, and secoisolariciresinol diglucoside (SDG) on (A) body weight and (B) oral glucose tolerance test. The vertical dotted grid line in (A) at week 8 represents the start of treatment for rats. Data are presented as mean ± SEM, n = 10–12. End-point means with different letters (a, b, c, or d) are significantly different, p < 0.05. C, corn starch diet-fed rats; CW, corn starch diet-fed rats treated with whole linseed; CD, corn starch diet-fed rats treated with defatted linseed; CS, corn starch diet-fed rats treated with SDG; H, high-carbohydrate, high-fat diet-fed rats; HW, high-carbohydrate, high-fat diet-fed rats treated with whole linseed; HD, high-carbohydrate, high-fat diet-fed rats treated with defatted linseed; HS, high-carbohydrate, high-fat diet-fed rats treated with SDG.