Table II. Selected genes differentially expressed in the parental strains and ΔSisArd1a.
| Gene | Description | arCOGb | p value | Fold change (ΔSisArd1/parent) | Up/down regulation |
|---|---|---|---|---|---|
| SiRe_0132 | ATPases involved in chromosome partitioning | D | 0.023 | 1.572 | Up |
| SiRe_0265 | ATPase, chromosome partitioning-like protein | D | 4.58E-04 | 0.211 | Down |
| SiRe_1174 | Cell division protein CdvB, Vps2 like protein | D | 0.010 | 0.224 | Down |
| SiRe_1175 | Cell division protein CdvC, Vps4 like protein | D | 0.011 | 0.526 | Down |
| SiRe_1550 | Cell division protein CdvB1, Vps2 like protein | D | 0.026 | 0.364 | Down |
| SiRe_0002 | ORC1-type DNA replication protein | L | 4.31E-05 | 0.133 | Down |
| SiRe_0061 | NurA 5′-3′ nuclease | L | 0.008 | 0.462 | Down |
| SiRe_0063 | DNA double-strand break repair protein Mre11 | L | 0.028 | 0.574 | Down |
| SiRe_0064 | Recombination repair enzyme HerA like protein | L | 0.015 | 0.527 | Down |
| SiRe_1129 | Nucleotide excision repair helicase, Xpb1 | L | 0.015 | 0.562 | Down |
| SiRe_1280 | Nucleotide excision repair nuclease, Xpf | L | 2.59E-04 | 0.567 | Down |
| SiRe_1451 | DNA polymerase B1 | L | 4.21E-04 | 0.562 | Down |
| SiRe_0323 | Transcriptional regulator PadR family protein | K | 0.047 | 1.973 | Up |
| SiRe_1000 | Transcriptional regulator, TrmB | K | 0.029 | 0.421 | Down |
| SiRe_1108 | Transcriptional regulator, AsnC family | K | 0.009 | 0.342 | Down |
| SiRe_1144 | Transcription initiation factor TFIIB | K | 0.044 | 0.277 | Down |
| SiRe_1402 | Transcription termination factor TFS | K | 4.62E-04 | 0.655 | Down |
| SiRe_1730 | Transcription factor E | K | 0.012 | 0.571 | Down |
| SiRe_1853 | Transcriptional regulator, AsnC family | K | 0.002 | 0.666 | Down |
| SiRe_1376 | Phosphoribosylamine-glycine ligase | F | 0.014 | 0.591 | Down |
| SiRe_1377 | Amidophosphoribosyltransferase | F | 0.015 | 0.545 | Down |
| SiRe_1378 | Amidophosphoribosyltransferase | F | 0.025 | 0.41 | Down |
| SiRe_1379 | Phosphoribosylformylglycinamidine synthase subunit, PurL | F | 0.023 | 0.373 | Down |
| SiRe_1381 | Phosphoribosylformylglycinamidine synthase subunit, PurS | F | 0.007 | 0.286 | Down |
| SiRe_0455 | CRISPR-associated protein, Csx14 | V | 0.004 | 1.699 | Up |
| SiRe_0598 | CRISPR-associated protein, Cmr2 family | V | 0.005 | 1.601 | Up |
| SiRe_0600 | CRISPR-associated RAMP protein, Cmr1 family | V | 0.005 | 1.664 | Up |
| SiRe_0601 | CRISPR-associated protein, Cmr5 family | V | 0.046 | 1.681 | Up |
| SiRe_0603 | CRISPR-associated protein Cmrx | V | 0.006 | 1.544 | Up |
| SiRe_0884 | CRISPR-associated (Cas) DxTHG family | V | 0.004 | 1.731 | Up |
| SiRe_0890 | CRISPR-associated RAMP protein, Cmr4 family | V | 0.006 | 1.937 | Up |
| SiRe_0891 | CRISPR-associated protein, Cmr5 | V | 0.009 | 1.673 | Up |
| SiRe_0892 | CRISPR-associated RAMP protein, Cmr1 family | V | 0.006 | 1.84 | Up |
| SiRe_0893 | CRISPR-associated RAMP protein, Cmr6 family | V | 0.004 | 1.696 | Up |
| SiRe_0894 | CRISPR-associated protein, Cmr2 family | V | 0.002 | 1.902 | Up |
| SiRe_0895 | CRISPR-assciated protein, Cmr3 | V | 0.003 | 1.608 | Up |
aGenes which encode putative functions in cell cycle control, nucleotide metabolism, replication, translation, repair and defense and were differentially expressed by >1.5 fold in the parental strain and ΔSisArd1 are included in the table.
bD, cell cycle control, cell division, chromosome partitioning; F, nucleotide transport and metabolism; L, replication, recombination and repair; K, transcription; V, defense mechanisms.