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Interaction of HMGB1-Osteocalcin-GPR158. Docking generated by Cluspro 2.0 of osteocalcin (blue), GPR158 (green is the extracellular outside part of the receptor, yellow the transmembrane domain, and purple the intracellular domain), and HMGB1 (red). The interaction of all three proteins is also shown and occurs at the transmembrane region of the GPR158.
