Fig. 2. Prediction accuracy for reduced observation intervals.

Correlation of prediction result achieved from reduced observation intervals ranging from one observation (baseline HAM-D) to the full set of either 17 HAM-D values (baseline through week 16, for MARS derived samples) or 13 HAM-D values (baseline through week 12, for GENDEP sample). Pearson correlations were calculated between clusters predicted using the reduced and predicted with the full observation interval, using the model-based HAM-D slope of the respective cluster. Note that a positive linear correlation of ≈0.50 was reached at week 2 and a correlation of ≈0.96 (for the MARS samples) and ≈0.77 (for GENDEP) was reached at week 8