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. 2019 Aug 5;10(8):589. doi: 10.1038/s41419-019-1809-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Chromogenic ISH of miR-425 expression in substantia nigra of PD brains and control; b Fluorescence ISH of miR-425 and colocalization with dopaminergic neurons in substantia nigra of PD brains and control; c–e Immunohistochemistry for RIPK1, RIPK3 and pMLKL in dopaminergic neurons in substantia nigra of PD brains and control; f Violin plots of miR-425, RIPK1, RIPK3, and pMLKL expression in substantia nigra of PD brains and control. Box plot with bars represent the mean ± SEM. Student’s t test, *P < 0.05, **P < 0.01, and ***P < 0.001