Table 2.
Rat NLRP1 allele sensitivity to anthrax lethal toxin, T. gondii, and VbP
| NLRP1 allele | Strains | Anthrax LT | T. gondii | VbP | |
|---|---|---|---|---|---|
| NLRP1 cleavage | MΦ pyroptosis | MΦ pyroptosis | MΦ pyroptosis (nM) | ||
| 1 | BN, WIS, SD, Dahl/SS | NT | Yes | Lowa | 257 |
| 2 | CDF | Yes | Yes | Lowa | 88 |
| 3 | ZUC | NT | No | NT | 4 |
| 4 | COP | NT | No | NT | 3 |
| 5 | LEW, WKY, SHR, SHR/Lj | No | No | High | 3 |
The sensitivities of the five known NLRP1 alleles from inbred rat strains to LT cleavage, LT-induced pyroptosis, T. gondii-induced pyroptosis, and VbP-induced pyroptosis. Data are from published reports15,17,30,31 and this study (IC50 values from Fig. 3b)
NT not tested
aT. gondii induces low levels of cell death and IL-1β release in these macrophages, but this response has not yet been definitely established as pyroptosis