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. 2019 Aug 5;10(8):587. doi: 10.1038/s41419-019-1817-5

Table 2.

Rat NLRP1 allele sensitivity to anthrax lethal toxin, T. gondii, and VbP

NLRP1 allele Strains Anthrax LT T. gondii VbP
NLRP1 cleavage MΦ pyroptosis MΦ pyroptosis MΦ pyroptosis (nM)
1 BN, WIS, SD, Dahl/SS NT Yes Lowa 257
2 CDF Yes Yes Lowa 88
3 ZUC NT No NT 4
4 COP NT No NT 3
5 LEW, WKY, SHR, SHR/Lj No No High 3

The sensitivities of the five known NLRP1 alleles from inbred rat strains to LT cleavage, LT-induced pyroptosis, T. gondii-induced pyroptosis, and VbP-induced pyroptosis. Data are from published reports15,17,30,31 and this study (IC50 values from Fig. 3b)

NT not tested

aT. gondii induces low levels of cell death and IL-1β release in these macrophages, but this response has not yet been definitely established as pyroptosis