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. 2019 Aug 5;9:11312. doi: 10.1038/s41598-019-47841-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Verification of the membrane disrupting effect of H₂O₂ as ROS is added to two different combinations of liposome samples measured by dynamic light scattering (DLS). (a) Relative frequency distributions of the liposome radius of monocomponent DPPC sample without and with 24% (m/m) H₂O₂ added furthermore the distribution in 30 min after the ROS addition. Curves are normalized to the height for easier comparison. (b) The same kind of distributions of DPPC₈₀ + DOPC₂₀ sample without and with 12% (m/m) H₂O₂ added furthermore the distribution in 30 min after the ROS addition. (SUV preparation method 1).