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. 2019 Aug 5;9:11339. doi: 10.1038/s41598-019-47762-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Effect of AURKB inhibition on renewal of depleted Mist1-positive acinar cells. The detrimental effect of AURKB inhibition on acinar renewal was confirmed with Mist1 staining. AURKB selective inhibition seized Mist1 transcriptional and protein levels in an injury-like status in the SMGs challenged with poly (I:C). Scale bar = 10 µm. (b) Effect of AURKB blockade on progenitor expansion. The K5⁺ progenitor compartment did not show similar dependence on AURKB for replenishment and expansion. Note that AZD1152-HPQA partly prevented the extensive expansion of K5 progenitors, 96 hrs post poly (I:C), in contrast to the Mist1-sustained depletion. Scale bar = 20 µm.