Table 3.
Outcome measure | Groups | |||
---|---|---|---|---|
STXBP1 full dataset (n = 8) | ID all (n = 33) | ID low ability (n = 8) | ||
MABC parent checklist | ||||
Motor competence (static environments) | Mean (SD) | 24.5 (12.3) | 18.45 (9.2) | 23.00 (5.6) |
Range | 3–42 | 1–37 | 11–31 | |
Motor competence (dynamic environments) | Mean (SD) | 26.00 (11.9) | 22.12 (8.8) | 25.5 (6.8) |
Range | 3–43 | 3–39 | 14–34 | |
Total motor score | Mean (SD) | 50.5 (23.6) | 40.61 (17.2) | 48.5 (10.9) |
Range | 6–85 | 6–74 | 35–62 | |
Conners (T score) | ||||
Inattention | Mean (SD) | 84.75 (7.5) | 79.19 (12.0) | 86.00 (5.3) |
Range | 72–92 | 55–90 | 79–90 | |
Hyperactivity | Mean (SD) | 85.25 (6.5) | 72.37 (15.0)# | 77.25 (13.2) |
Range | 73–90 | 40–90 | 56–90 | |
Learning problems | Mean (SD) | 86.38 (8.3) | 79.44 (10.9) | 86.13 (5.0) |
Range | 66–90 | 57–90 | 78–90 | |
Executive functions | Mean (SD) | 76 (14.8) | 64.56 (14.4) | 66.25 (13.3) |
Range | 54–90 | 43–90 | 48–83 | |
Aggression | Mean (SD) | 59.88 (17.4) | 52.3 (10.5) | 47.5 (4.8) |
Range | 44–90 | 44–83 | 44–58 | |
Peer relations | Mean (SD) | 84.13 (7.2) | 80.33 (15.0) | 81.38 (16.1) |
Range | 72–90 | 45–90 | 45–90 | |
DBC (percentile/stratified by ID severity) | ||||
Disruptive | Mean (SD) | 68.25 (24.3) | 50.91 (28.8) | 54.00 (25.2) |
Range | 28–90 | 4–98 | 26–90 | |
Self-absorbed | Mean (SD) | 73.75 (19.2) | 70.12 (25.8) | 77.75 (17.9) |
Range | 34–94 | 10–100 | 40–100 | |
Communication | Mean (SD) | 75.5 (17.8) | 76.42 (23.1) | 78.00 (18.8) |
Range | 48–96 | 6–100 | 40–92 | |
Anxiety | Mean (SD) | 42.5 (24.5) | 58.3 (26.9) | 66.25 (30.1) |
Range | 12–76 | 10–100 | 10–96 | |
Social relations | Mean (SD) | 49.5 (22.8) | 58.85 (28.0) | 57.00 (27.3) |
Range | 24–96 | 12–100 | 24–98 | |
Total problems | Mean (SD) | 73.50 (24.1) | 63.94 (27.4) | 67.25 (22.3) |
Range | 30–94 | 0–100 | 38–98 | |
SRS (T score) | ||||
Social awareness | Mean (SD) | 78.75 (5.9) | 73.64 (11.2) | 76.38 (12.3) |
Range | 70–87 | 49–93 | 56–92 | |
Social cognition | Mean (SD) | 73.88 (11.5) | 72.7 (11.0) | 74.38 (6.6) |
Range | 53–92 | 47–96 | 67–85 | |
Social communication | Mean (SD) | 76.25 (9.2) | 72.7 (11.7) | 80.88 (11.1) |
Range | 66–90 | 50–96 | 67–96 | |
Social motivation | Mean (SD) | 58.00 (13.6) | 64.52 (11.8) # | 69.5 (13.6)# |
Range | 45–89 | 41–95 | 58–95 | |
RRB | Mean (SD) | 79.00 (11.9) | 78.36 (15.2) | 87.38 (14.7) |
Range | 62–92 | 48–108 | 72–108 | |
SRS total score | Mean (SD) | 77.75 (9.3) | 75.12 (12.0) | 81.75 (10.9) |
Range | 66–94 | 49–98 | 70–98 |
#Comparison to STXBP1 full dataset group, Mann-Whitney U test, P < 0.05