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. 2019 Aug 6;14:247. doi: 10.1186/s13018-019-1278-7

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Downregulation of MIR4435-2HG effectively distinguished osteoarthritis patients from healthy controls. MIR4435-2HG in joint fluid was also measured by qPCR. It was observed that expression levels of MIR4435-2HG in join fluid were also significantly lower in osteoarthritis patients than in the control group (a). ROC curve analysis showed that downregulation of MIR4435-2HG effectively distinguished osteoarthritis patients from healthy controls (b). (*p < 0.05)