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. 2019 Aug 5;16:162. doi: 10.1186/s12974-019-1551-z

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Multiple sclerosis risk-associated amino acid positions of the HLA genes. Diamonds represent the –log₁₀(P) of the amino acid positions of the tested HLA genes. Labeled red diamonds represent the –log₁₀(P) values of the amino acid positions significantly associated with MS. The horizontal lines represent the association P value of HLA-DRB1*15:01. a No amino acid polymorphisms of HLA-B was significantly associated with MS. b No amino acid polymorphisms of HLA-DRB1 is significantly associated with MS. c The HLA-DQβ1 position 9 and 70 were associated with MS more significantly than HLA-DRB1*15:01