Table 2.
HLA association analysis of multiple sclerosis in the Japanese population
| Variant | Frequency | Nominal analysis | |||
|---|---|---|---|---|---|
| HLA gene | MS (n = 45) | Control (n = 429) | OR (95% CI) | P | Fisher |
| HLA-B*15:01 | 0.200 | 0.078 | 2.95 (1.66–5.24) | 2.2 × 10−4 | |
| HLA-B*39:01 | 0.122 | 0.043 | 3.09 (1.52–6.29) | 0.0019 | |
| HLA-B*52:01 | 0.044 | 0.127 | 0.32 (0.08–0.88) | 0.017 | * |
| HLA-C*07:02 | 0.233 | 0.145 | 1.80 (1.07–3.04) | 0.028 | |
| HLA-C*12:02 | 0.044 | 0.127 | 0.32 (0.08–0.88) | 0.017 | * |
| HLA-DMB*01:07 | 0.044 | 0.008 | 5.64 (1.19–22.7) | 0.015 | * |
| HLA-DOA*01:01 | 0.978 | 0.997 | 0.15 (0.03–0.94) | 0.042 | |
| HLA-DPB1*05:01 | 0.522 | 0.356 | 1.98 (1.28–3.07) | 0.0021 | |
| HLA-DQA1*01:02 | 0.267 | 0.156 | 1.96 (1.19–3.25) | 0.0084 | |
| HLA-DQA1*03:03 | 0.222 | 0.141 | 1.74 (1.02–2.96) | 0.042 | |
| HLA-DQB1*03:01 | 0.033 | 0.104 | 0.30 (0.06–0.93) | 0.037 | * |
| HLA-DQB1*04:01 | 0.222 | 0.100 | 2.56 (1.49–4.42) | 7.0 × 10−4 | |
| HLA-DQB1*06:02 | 0.200 | 0.068 | 3.45 (1.93–6.17) | 3.0 × 10−5 | |
| HLA-DRA*01:01 | 0.733 | 0.579 | 2.00 (1.23–3.25) | 0.0053 | |
| HLA-DRA*01:02 | 0.267 | 0.421 | 0.50 (0.31–0.81) | 0.0053 | |
| HLA-DRB1*04:05 | 0.233 | 0.120 | 2.23 (1.31–3.79) | 0.0030 | |
| HLA-DRB1*15:01 | 0.211 | 0.072 | 3.44 (1.95–6.07) | 2.1 × 10−5 | |
| HLA-DRB1*15:02 | 0.033 | 0.120 | 0.25 (0.05–0.79) | 0.012 | * |
*Fisher’s exact test was used for association analysis, otherwise logistic regression was used