Table 5.
HLA association analysis of neuromyelitis optica spectrum disorder in the Japanese population
| Variant | Frequency | Nominal analysis | |||
|---|---|---|---|---|---|
| HLA gene | NMOSD (n = 31) | Control (n = 429) | OR (95% CI) | P | Fisher |
| HLA-A*26:03 | 0.065 | 0.020 | 3.40 (0.81–10.9) | 0.047 | * |
| HLA-B*07:02 | 0.129 | 0.059 | 2.34 (1.06–5.19) | 0.036 | |
| HLA-DPB1*05:01 | 0.516 | 0.356 | 1.93 (1.15–3.24) | 0.012 | |
| HLA-DQA1*01:01 | 0.129 | 0.058 | 2.39 (1.08–5.30) | 0.031 | |
| HLA-DQA1*03:02 | 0.048 | 0.147 | 0.30 (0.06–0.93) | 0.035 | * |
| HLA-DQA1*05:03 | 0.097 | 0.015 | 6.96 (2.55–19.0) | 1.5 × 10−4 | |
| HLA-DQB1*03:01 | 0.210 | 0.104 | 2.29 (1.20–4.39) | 0.012 | |
| HLA-DQB1*03:03 | 0.048 | 0.149 | 0.29 (0.06–0.91) | 0.024 | * |
| HLA-DRB1*01:01 | 0.129 | 0.058 | 2.39 (1.08–5.30) | 0.031 | |
| HLA-DRB1*09:01 | 0.016 | 0.135 | 0.10 (0.003–0.62) | 0.0027 | * |
| HLA-DRB1*14:06 | 0.081 | 0.012 | 7.40 (1.92–24.8) | 0.0021 | * |
*Fisher’s exact test was used for association analysis, otherwise, logistic regression was used