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. 2019 Aug 6;51:36. doi: 10.1186/s12711-019-0477-3

Table 5.

Predicted number of homozygous offspring (aa) with standard errors (SE) for different percentages of herd genotyped in three scenariosa given two selection strategiesb

Level of genotyping % Herd genotyping Predicted number of homozygous individuals per 100 matings (aa)
A B C
Base 0 0.70 (0.000) 12.45 (0.000) 15.22 (0.000)
Strategyb 1 2 1 2 1 2
Low 10 0.70 (0.003) 0 (0.000) 9.11 (0.003) 8.17 (0.003) 12.42 (0.003) 6.77 (0.003)
20 0.70 (0.003) 0 (0.000) 7.43 (0.003) 7.48 (0.002) 6.06 (0.003) 5.97 (0.003)
30 0.70 (0.003) 0 (0.000) 6.08 (0.003) 6.47 (0.003) 6.05 (0.003) 5.92 (0.003)
Intermediate 40 0.70 (0.003) 0 (0.000) 5.21 (0.003) 5.69 (0.003) 4.80 (0.003) 4.87 (0.002)
50 0.70 (0.003) 0 (0.000) 5.05 (0.003) 5.12 (0.002) 4.75 (0.003) 3.87 (0.003)
60 0.70 (0.003) 0 (0.000) 4.58 (0.003) 4.59 (0.002) 4.7 5(0.003) 3.87 (0.003)
High 70 0.35 (0.003) 0 (0.000) 4.06 (0.003) 4.09 (0.002) 4.75 (0.003) 3.84 (0.003)
80 0.35 (0.003) 0 (0.000) 4.01 (0.002) 3.53 (0.002) 4.35 (0.003) 3.23 (0.003)
90 0.35 (0.002) 0 (0.000) 3.68 (0.003) 3.23 (0.002) 4.35 (0.002) 1.89 (0.001)
100 0.35 (0.003) 0 (0.000) 3.61 (0.003) 2.89 (0.002) 4.25 (0.003) 1.83 (0.002)

aScenario A (7 loci with high-frequency LOF alleles), scenario B (76 loci with low-frequency LOF alleles), and scenario C (50 with high- and low-frequency loci)

bSelection against carrier parents (strategy 1) and selection and mate allocation to avoid homozygous offspring (strategy 2)