Table 2.

Published Literature on the Burden of Respiratory Syncytial Virus in Long-term Care Facilities

Author, Publication Year	Study Design	Country	Study Dates	Type of study	Age, Mean (SD)a, in years	n Infected / N at Riskb	Incidence Estimates
Sorvillo et al., 1984 [30]	Retrospective Cohort	United States	February–April 1979	Outbreak	79.2	13 / 101	12.9%
Ellis et al., 2003 [31]	Retrospective Cohort	United States	August 1, 1995 - July 31, 1999	Non-outbreak	Age ≥ 65, 100%	1105 infections / 88,851 person-yearsc	12.4 cases per 1000 person-years
McElhaney et al., 2004 [39]	Randomized Controlled Trial	United States	2000–2001d	Non-outbreak	82.2 (8.4)	3 / 198	1.5%
Caram et al., 2009 [18]	Prospective Cohort	United States	January 29, 2008 - February 26, 2008	Outbreak	70.8 (15.0)	7 / 52	13.5%
Johnstone et al., 2014 [17]	Prospective Cohort	Canada	2009, 2010, 2011e	Non-outbreak	Median 86 (IQR 80–90)	12 / 1072	1.1%
Uršič et al., 2016 [19]	Prospective Cohort	Slovenia	December 5, 2011 - May 31, 2012	Non-outbreak	Median 84 (IQR 79.8–88.8)	5 / 90	5.6%
Hui et al., 2008 [20]	Prospective Cohort	China	April 2006–March 2007	Non-outbreak	84.9 (8.9)	21 / 194	10.8%

^aIf available and unless another measure is specified

^bThe estimates and study participants’ characteristics were calculated among the unvaccinated individuals

^cOnly the number of person-years contributed by study sample was reported, not the number of individuals in the sample

^dThe published paper stated that study participants were enrolled in September or October and followed to the end of the respiratory viral season

^eParticipants were enrolled from mid-February through mid-March in 2000 for the first influenza season and trial. Then, a second trial was initiated in late December 2000 during a second influenza season, but the time period of enrollment was not reported