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. 2019 Aug 6;10:237. doi: 10.1186/s13287-019-1301-2

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 8 — A mechanism map depicting the molecular mechanism of BMP2 in HCC. BMP2 expresses highly in HCC, and the BMP2 secretion from HepG2 into ECV304 cells, then activates the MAPK/p38 signaling pathway, which acts to increase VEGF expression, consequently promoting angiogenesis and tumor growth in HCC