Table 2.
Physicochemical parameters of liposomes
| LV | LysLV | LysL | |
|---|---|---|---|
| Particle size (nm) | 198±2.1 | 211.4±5.5 | 193.9±1.3 |
| PDI | 0.085±0.03 | 0.15±0.09 | 0.177±0.02 |
| Zeta potential (mV) | 0 | 0.4±0.1 | 0.3±0.2 |
| EE (%) | 62.5±5.3 | 60±5 | - |
| CE (%) | - | 73.1±4 | 70±3 |
| No. Lys/vesicle | - | 52±6 | 49 ±7 |
Abbreviations: LV, liposomal vancomycin; LysLV, lysostaphin-conjugated liposomal vancomycin; LysL, lysostaphin-conjugated liposomes without vancomycin; PDI, polydispersity index; EE, encapsulation efficiency; CE, conjugation efficiency; No. Lys/Vesicle, number of lysostaphin conjugated to each vesicle.