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. 2019 Jul 19;151(8):970. doi: 10.1085/jgp.201912432

graphic file with name JGP_201912432_Fig1.jpg

Miriam Bell (left), Padmini Rangamani (right), and colleagues develop a 3-D multicompartment reaction–diffusion model of calcium dynamics in dendritic spines. The model shows that altering the shape of the spine head or the specialized ER known as the spine apparatus has complex, nonlinear effects on calcium’s spatial distribution 5 ms after stimulation.