Table 1.
Characteristics of children with higher eGFR compared with lower eGFR at dialysis initiation
| Characteristics | Higher eGFR at Dialysis Initiation (n=4327) | Lower eGFR at Dialysis Initiation (n=10,843) | P Value |
|---|---|---|---|
| eGFR (ml/min per 1.73 m2), median (IQR) | 12.8 (11.1–16.0) | 6.5 (4.8–8.0) | <0.001 |
| Median age in years (IQR) | 14 (9–16) | 14 (10–17) | <0.001 |
| Age category, N (%) | <0.001 | ||
| Age 1 to <5 yr | 572 (13.2) | 928 (8.6) | |
| Age 5 to <13 yr | 1261 (29.1) | 2937 (27.1) | |
| Age ≥13 yr | 2494 (57.6) | 6978 (64.4) | |
| Girls, N (%) | 2173 (50.2) | 4850 (44.7) | <0.001 |
| Race/ethnicity, N (%) | <0.001 | ||
| Non-Hispanic white | 1945 (45.0) | 4082 (37.6) | |
| Non-Hispanic black | 1023 (23.6) | 3046 (28.1) | |
| Hispanic | 1107 (25.6) | 3108 (28.7) | |
| Asian | 164 (3.8) | 437 (4.0) | |
| Other/unknown | 88 (2.0) | 170 (1.6) | |
| Primary cause of ESRD, N (%) | <0.001 | ||
| GN | 2012 (46.5) | 4484 (41.3) | |
| CAKUT | 1219 (28.2) | 3232 (29.8) | |
| Diabetes | 26 (0.6) | 71 (0.7) | |
| Hypertension | 121 (2.8) | 526 (4.8) | |
| Malignancy | 59 (1.3) | 71 (0.7) | |
| Other or unknown | 890 (20.6) | 2459 (22.7) | |
| BMI category by z-score, N (%) | 0.01 | ||
| <5th% (underweight) | 542 (12.5) | 1231 (11.4) | |
| 5th%–94th% (normal weight) | 2757 (63.7) | 7180 (66.2) | |
| ≥95th% (obese) | 1028 (23.8) | 2432 (22.4) | |
| Mean serum albumin (g/dl), (SD)a | 3.2 (1.1) | 3.3 (1.3) | <0.001 |
| Median hemoglobin (g/dl), (IQR)b | 9.9 (8.6, 11.2) | 9.1 (7.7, 10.6) | <0.001 |
| Comorbidity, N (%) | |||
| Hypertensionc | 2002 (47.0) | 4763 (44.7) | 0.01 |
| Cardiovascular diseased | 279 (6.5) | 504 (4.7) | <0.001 |
| Other comorbiditiese | 339 (7.8) | 492 (4.5) | <0.001 |
| Distance between patient and dialysis center (miles), median (IQR) | 15.1 (6.3, 45.0) | 14.1 (5.8, 41.0) | <0.001 |
| Insurance, % (N) | |||
| Medicaid | 2369 (54.8) | 5305 (48.9) | <0.001 |
| None | 147 (3.4) | 999 (9.2) | <0.001 |
| PD modality, N (%)f | 1805 (42.2) | 4179 (39.2) | 0.001 |
CAKUT, congenital anomalies of the kidney and urinary tract.
a
Missing in n=2231.
b
Missing in n=1019.
c
Missing in n=266.
d
Cardiovascular disease includes stroke, heart failure, coronary artery disease, peripheral vascular disease, and other cardiac disease.
e
Other comorbidities include cancer, diabetes, immobility, tobacco, alcohol or drug use, and chronic obstructive pulmonary disease.
f
Missing in n=239.