Figure 9.

Summary of potential rapid signaling mechanisms of aldosterone in the DCT. The nonbiased proteomics data were combined with data from immunoblotting experiments and current literature to generate a simplified hypothetical signaling pathway for rapid aldosterone effects in DCT cells. GPR30 and EGFR are involved in mediating some of the rapid effects of aldosterone, but a role for the MR, the other seven transmembrane receptors (7TMR), or matrix metalloproteinases (MMPs) requires further investigation. Dashed lines or question marks indicate potential pathways of aldosterone signaling that need further investigation.