Table 2.
Clinical characteristics and biologic data of participants
| Characteristic | HS (n=82) | Het (n=81) | GS (n=79) | ANOVA P Value |
|---|---|---|---|---|
| Plasma | ||||
| Creatinine, µmol/L | 66 [59; 76]a | 65 [56; 73] | 59 [50; 72] | 0.009 |
| eGFR, ml/min per 1.73 m2 | 92 [81; 110] | 102 [92; 99] | 99 [86; 110] | 0.1 |
| Sodium, mmol/L | 140 [139; 139]a | 140 [139; 142]a | 139 [138; 141] | 0.007 |
| Potassium, mmol/L | 4.0 [3.8; 4.2]b | 3.9 [3.8; 4.1]b | 2.8 [2.5; 3.1] | <0.001 |
| CO2t, mmol/L | 27 [26; 28]b | 27 [26; 29]b | 30 [28; 32] | <0.001 |
| Calcium, mmol/L | 2.24 [2.18; 2.29]b | 2.26 [2.22; 2.34]b,c | 2.34 [2.26; 2.39] | <0.001 |
| Magnesium, mmol/L | 0.82 [0.78; 0.86]b | 0.79 [0.75; 0.83]b | 0.59 [0.51; 0.67] | <0.001 |
| PTH 7–84, pg/ml | 44 [34; 55]b | 39 [31; 46]b | 31 [24; 39] | <0.001 |
| PRC, mUI/L | 15 [9; 21]b | 15 [11; 21]b | 109 [52; 156] | <0.001 |
| PAC, pmol/L | 178 [136; 235]b | 216 [155; 308]b | 311 [238; 530] | <0.001 |
| Urinary excretion | ||||
| Output, L/24 h | 1.6 [1.1; 1.9]a | 1.5 [1.0; 2.2] | 1.7 [1.4; 2.3] | 0.03 |
| Creatinine, mmol/24 h | 11.9 [9.0; 15.0] | 11.3 [9.2; 14.2] | 11.8 [9.9; 15.3] | 0.56 |
| Sodium, mmol/24 h | 147 [99; 172]b | 140 [96; 192]b | 183 [105; 246] | 0.001 |
| Potassium, mmol/24 h | 59 [44; 75]b | 59 [47; 79]b | 108 [92; 154] | <0.001 |
| Calcium, mmol/24 h | 3.8 [2.6; 5.6]b | 3.5 [2.2; 5.2]b | 1.1 [0.7; 2.0] | <0.001 |
| Calcium-to-creatinine ratio, mM/mM | 0.32 [0.23; 0.52]b | 0.33 [0.19; 0.45]b | 0.09 [0.05; 0.18] | <0.001 |
| Magnesium, mmol/24 h | 3.4 [2.5; 4.2]b | 3.3 [2.7; 4.2]b | 4.4 [3.6; 6.1] | <0.001 |
| Aldosterone, nmol/24 h | 56 [33; 87]b | 67 [47; 97]b | 95 [72; 172] | <0.001 |
eGFR calculated with cystatin C-based CKD Epidemiology Collaboration. Data are presented as median [IQR]. Difference between groups was evaluated first with ANOVA. If significant, Dunn test was performed to compare HS versus GS and Het versus GS (a,b) and Tukey test was performed to compare HS and Het (c). CO2t, Total CO2; PRC, plasma renin concentration; PAC, plasma aldosterone concentration.
a
P<0.05.
b
P<0.001.
c
P<0.05.