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. 2019 Jul 19;218(8):2437–2438. doi: 10.1083/jcb.201906115

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© 2019 Pereira and Arraiano

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

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Figure 1. — Regulation of hESC differentiation and pluripotency by the RNA exosome. Belair et al. show that the RNA exosome acts by regulating the cellular levels of several RNA classes (mRNAs, lncRNAs, and pri-miRNAs) and, consequently, the levels of certain TFs with relevance in inducing pluripotency and differentiation in hESCs. Pri-miR-205, primary miRNA transcript 205.