Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jul 17;218(8):2456–2469. doi: 10.1083/jcb.201903066

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 Chang and Chaudhuri

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 1. — BM composition, mechanics, and associated cell interactions. (A) During metastasis, tumor cells breach through the BM during primary tumor escape, intravasation, and extravasation. Inset corresponds to events described in B. (B) Cell integrin receptors bind to a laminin network, which binds to a collagen IV network via nidogen. Proteoglycans are also found within the BM, and collagen I is primarily found in the stromal matrix.