Figure 2.

Therapeutic strategies to target EVs for cancer treatment. There are a number of potential ways to target the EV-mediated intercellular communication. (A) EV biogenesis or release can be targeted via interfering the specific components involved in EV production or surface shedding. (B) EVs can be targeted and specifically removed from the circulation using different substances, i.e., specific antibodies. (C) EV uptake/internalization by the recipient cells can be interrupted by targeting the EV ligands or cell surface receptors.