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. 2019 Jul 30;9:695. doi: 10.3389/fonc.2019.00695

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Copyright © 2019 Schroeder, Bittrich, Noebel, Kuhne, Schroeder, Schoen, Fiehler, Kniep and Gellißen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Flow-chart summarizing patient selection in the study (A) and distribution of patients who received GC (GC-pos) and who did not (GC-neg) with corresponding number of brain metastases (BM) and edema (VE, B). Only VE without connection to an adjacent VE (NC-VE) were segmented and included in final analysis (thick boxes). BM, brain metastases; C-VE, confluent vasogenic edema; GC-neg, patient did not receive glucocorticoids; GC-pos, patient received glucocorticoids; MRI, magnetic resonance imaging; NC-VE, non-confluent vasogenic edema; y, years.