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. 2019 Jul 30;10:955. doi: 10.3389/fphys.2019.00955

Figure 1.

Figure 1

Interneuron development in the cortex and subcortical white matter of the damaged preterm brain is altered compared with age-matched cases without white matter injury. Cell counts were performed in cortical and subcortical white matter in the frontal lobe, anterior to Ammon’s Horn. Total cortical neuronal number was assessed counting HuC/HuD positive neurons (A,C). A significant decrease in Calretinin (CalR)-positive interneurons was observed in the cortex of preterm brains with non-cystic white matter injury (WMI) compared with no WMI controls (B,D). No significant difference in Somatostatin (SST) or Neuropeptide Y (NPY)-positive interneurons was observed in the subcortical white matter. However, SST and NPY labeled interneurons from non-cystic white matter injury showed shorter neurites, with fewer branches (E,F). Data presented as mean ± SD; scale bar = 100 μm (A–D), 25 μm (E,F); *p < 0.05, **p < 0.01, ***p < 0.001; SST, somatostatin; NPY, neuropeptide Y; WMI, white matter injury.