Table 1.
Summary of clinical information of human postmortem cases.
| Group | Sex | GA at birth (weeks) | Postnatal age | PMA at death (weeks) | Clinical context | Neuropathology |
|---|---|---|---|---|---|---|
| No white matter injury | ||||||
| 1 | M | 23 + 2 | 5 min | 23 + 2 | Ass IUGR, oligohydramnios, congestive heart failure | |
| 2 | M | 23 + 6 | 9 h 51 min | 23 + 6 | Ass IUGR (twin) | Leptomeninges congested with focal hemorrhages |
| 3 | F | 24 + 1 | 4 h 40 min | 24 + 1 | Extreme prematurity, congestive heart failure | |
| 4 | M | 24 + 2 | IUD/stillbirth | 24 + 2 | Constricted umbilical cord, congestive heart failure | |
| 5 | M | 25 + 3 | 21 h 7 min | 25 + 3 | Ass IUGR (twin) | Odematous brain with transtentorial herniation of the unci |
| 7 | M | 26 + 2 | 43 h | 26 + 3 | TTT, Ass IUGR, pulmonary hemorrhage | |
| 8 | M | 28 + 1 | <1 h | 28 + 1 | Oligohydramnios, lung hypoplasia, congestive heart failure | |
| Non-cystic white matter injury | ||||||
| 1 | M | 26 + 5 | 1 days 7 h 52 min | 26 + 6 | Ass IUGR, oligohydramnios, congestive heart failure | PVWM injury/pathology in PVWM at angles of the lateral ventricle |
| 2 | M | 24 + 6 | 16 days 19 h 10 min | 27 + 0 | AAAFI, PPROM, acute necrotizing pneumonia | PVWM injury/pathology in PVWM at angles of the lateral ventricle |
| 3 | M | 24 + 0 | 5 weeks 1 day 8 h 25 min | 29 + 1 | AAAFI, retroplacental hemorrhage | PVWM injury/pathology in PVWM at angles of the lateral ventricle |
| 4 | M | 29 + 3 | 11 h 17 min | 29 + 3 | TTT, AAAFI, hydrops fetalis | GM/IVH |
| 5 | M | 27 + 5 | 12 days | 29 + 4 | Ass IUGR, necrotizing entercolitis, uterine constraint/oligohydramnios | PVWM injury/pathology in PVWM at angles of the lateral ventricle |
| 6 | M | 26 + 0 | 1 min | 30 + 0 | Necrotizing enterocilitis | Patchy WM gliosis |
Ass IUGR, asymmetric interauterine growth restriction; AAAFI, acute ascending amniotic fluid infectin; GM, germinal matrix; IVH, intraventricular hemorrhage; PPROM, preterm premature rupture of the membranes; PVMW, periventricular white matter; TTT, twin-twin transfusion; WM, white matter.