Table 3.
Stratified analyses of relation between hepatocellular cancer and rs1128503 or rs1045642 polymorphism in MDR1 under different genetic models.
| Subgroup | N | Allele (C vs. T) |
Homozygous model (CC vs. TT) |
Heterozygous model (CT vs. TT) |
Recessive model (CC vs. CT + TT) |
Dominant model (CC + CT vs. TT) |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P (OR) | I2 (%) | OR (95% CI) | P (OR) | I2 (%) | OR (95% CI) | P (OR) | I2 (%) | OR (95% CI) | P (OR) | I2 (%) | OR (95% CI) | P (OR) | I2 (%) | ||
| rs1128503 T>C | ||||||||||||||||
| Ethnicity | ||||||||||||||||
| Asian | 2 | 1.15 (0.83, 1.58) |
0.409 | 43.4 | 1.24 (0.68, 2.26) |
0.484 | 29.0 | 1.06 (0.64, 1.82) |
0.784 | 0.0 | 1.18 (0.69, 2.03) |
0.543 | 65.3 | 1.18 (0.74, 1.88) |
0.499 | 0.0 |
| Caucasian | 2 | 0.82 (0.67, 1.01) |
0.063 | 0.0 | 0.64 (0.42, 0.98) |
0.039 | 12.4 | 0.64 (0.44, 0.94) |
0.024 | 48.2 | 0.89 (0.65, 1.21) |
0.449 | 0.0 | 0.64 (0.45, 0.93) |
0.017 | 47.4 |
| Control type | ||||||||||||||||
| Healthy | 2 | 0.93 (0.74, 1.17) |
0.524 | 0.0 | 0.84 (0.53, 1.32) |
0.447 | 0.0 | 0.97 (0.66,1.43) |
0.883 | 0.0 | 0.88 (0.61, 1.28) |
0.510 | 0.0 | 0.93 (0.65, 1.34) |
0.710 | 0.0 |
| Others | 2 | 0.88 (0.67, 1.14) |
0.324 | 79.6 | 0.75 (0.44, 1.26) |
0.269 | 81.3 | 0.51 (0.30, 0.86) |
0.011 | 0.0 | 1.04 (0.70, 1.57) |
0.835 | 69.9 | 0.64 (0.40, 1.01) |
0.058 | 71.7 |
| rs1045642 T>C | ||||||||||||||||
| Controls type | ||||||||||||||||
| Healthy | 2 | 1.15 (0.84, 1.56) |
0.379 | 20.2 | 1.26 (0.67, 2.36) |
0.473 | 32.7 | 0.89 (0.49, 1.61) |
0.702 | 63.0 | 1.33 (0.85, 2.10) |
0.214 | 0.0 | 1.02 (0.58, 1.78) |
0.946 | 65.1 |
| others | 1 | 0.91 (0.48, 1.72) |
0.774 | NU | 0.92 (0.31, 2.72) |
0.876 | NU | 1.15 (0.33, 3.95) |
0.829 | NU | 0.85 (0.36, 2.01) |
0.714 | NU | 0.99 (0.35, 2.77) |
0.980 | NA |
N, number of comparisons; OR, odds ratio; CI, confidence interval; NU, null, NA, not available.