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. 2019 Jul 2;47(7):3307–3319. doi: 10.1177/0300060518789819

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© The Author(s) 2019

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — KIF3A downregulation and miR-145-5p upregulation were detected in airway epithelial cells in HDM-exposed mice with asthma, while miR-145-5p antagonism markedly improved asthma symptoms. (a) Schematic workflow chart for experimental design. (b) miR-145-5p expression was measured by qRT-PCR. (c) KIF3A mRNA and protein expression was determined by qRT-PCR and western blot analysis, respectively. (d) Lung tissue sections were stained with KIF3A immunohistochemistry, H&E, and PAS stains. (e) Total eosinophil and neutrophil numbers. (f) Levels of IL-4, IL-5, and IL-3. (g) Lung resistance is presented as a percentage change over baseline measured in response to inhaled acetylcholine. **P < 0.01, compared with control; ^##P < 0.01, ^#P < 0.05 compared with Ant-scrambled.