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. 2019 Apr 22;6(4):211–219. doi: 10.1093/rb/rbz013

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© The Author(s) 2019. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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PEG-4MAL Hydrogels release therapeutics in a formulation and protease-dependent manner. (A) Fluorescent particle release over time imaged by IVIS. (B) Flow cytometry analysis of nanoparticle release from PEG-4MAL hydrogels when exposed to collagenase as a function of protease concentration and crosslinker composition (percentage of DTT vs. VPM). (C) Scatter plot comparing particle release over time of hydrogels fabricated with 50% VPM vs. 100% VPM hydrogels. All groups used n = 4 hydrogels; *P < 0.05 compared to all other groups.