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. 2019 Aug 2;11:7307–7315. doi: 10.2147/CMAR.S210545

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© 2019 Chai et al.

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LOX-1 defines a subset of PMN-MDSC in GBM patient tissues. (A) Typical example of the analysis of PMN in GBM patient tissue. (B, C) Suppressive function of LOX-1+ and LOX-1− PMN sorted from tumor tissue of GBM patients in allogeneic MLR. CD4+T cell (B) and CD8+ T cell (C) proliferation was determined in triplicates using 3H-thymidine uptake. (D) Production of ROS in LOX-1+ and LOX-1− PMN from five patients with GBM. Production of ROS was detected by staining with DCFDA. (E, F) ARG1 (E) and iNOS (F) expression in LOX-1- and LOX-1+ PMN from five patients with GBM detected by qPCR. *P<0.05, **P<0.01, ***P<0.001.

Abbreviations: LOX-1, lectin-type oxidized LDL receptor 1; PMN, polymorphonuclear neutrophil; GBM, glioblastoma multiforme; MDSC, myeloid-derived suppressor cell; DCFDA, dichlorodihydrofluorescein diacetate; MLR, mixed lymphocyte reaction; n.s, not significant.